In the article in order to identify the theoretical and methodological foundations of the philosophy of the future is carried out a comparative analysis of the concepts of S. Huntington, F. Fukuyama and I. Wallerstein. The modern political process is most adequately reflected by the post-nonclassical ideas of I. Wallerstein, anticipating the crisis of liberalism and the need to transform the foundations of Western democracy, the collapse of the paradigms of the development of capitalism, the growth of the relationship between populism and authoritarianism, the emergence of a new transitional period characterized by system disorder (chaos), acute political struggle based on the principle “ All against all” , the lack of peaceful coexistence, stability and legality. The future appears as a bundle of scenarios of varying degrees of probability, only some of which, bypassing the zone of uncertainty, can take place. The second part of the article discusses the issues of determining the future by previous events, highlighting the main and peripheral events that lay in the foundation for the future. It is noted that even before the pandemic in the world became noticeable the flaws of democracy, the growth of anti-liberal and anti-globalization sentiments, which led to national isolation, the strengthening of xenophobia, contributing to the rise of authoritarian regimes and their image in the populist plan. It is emphasized that the majority of modern forecasts are of an alarmist nature, they are value-colored with deep pessimism and apocalyptic sentiments. Each country will have to cope with the threats independently, since the world, confirming Wallerstein's predictions, must go through destructive processes to establish a new order.

The Oxford classification for IgA nephropathy (IgAN) does not currently include thrombotic microangiopathy (TMA) as a parameter, despite evidence that TMA can occur in IgAN patients and impact outcomes. Prior studies have found that a significant proportion of IgAN patients have histological evidence of TMA, either acute or organized, in their renal biopsies. Moreover, patients with TMA lesions in IgAN tend to have worse outcomes, including a greater percentage of sclerotic glomeruli, more tubulointerstitial fibrosis, and higher rates of doubling of serum creatinine or progression to end-stage renal disease compared to IgAN patients without TMA. Other researchers have suggested that TMA in IgAN is commonly located in the advanced steps of the disease and may be accompanying by severe hypertension and proteinuria. However, the Oxford system does not include TMA as a parameter. Therefore, further investigations are required to determine the clinical significance and optimal management of TMA in IgAN individuals. Renal arteriolar microangiopathic lesions can occur in immunoglobulin A nephropathy, but their role in disease progression has been unclear. Furthermore, the main limitation of the MEST-C classification is that it does not currently account for the presence and impact of TMA in IgAN, despite evidence that TMA is a common and clinically relevant histological finding in these patients.